Phosphoinositide 3-kinase inhibitors in lymphoma
نویسندگان
چکیده
منابع مشابه
Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.
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Phosphoinositide 3-kinases (PI3-Ks) are an ubiquitous class of signaling enzymes that regulate diverse cellular processes including growth, differentiation, and motility. Physiological roles of PI3-Ks have traditionally been assigned using two pharmacological inhibitors, LY294002 and wortmannin. Although these compounds are broadly specific for the PI3-K family, they show little selectivity amo...
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متن کاملThe role of phosphoinositide 3-kinase pathway inhibitors in the treatment of lung cancer.
The phosphoinositide 3-kinase signaling network is widely implicated in the pathogenesis of human cancer. This pathway is commandeered by cancer cells to promote unrestrained cellular growth and survival. In this brief review, we speculate about the uses of inhibitors of phosphoinositide 3-kinase signaling as treatments for human cancers, with an emphasis on non-small cell lung cancer.
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ژورنال
عنوان ژورنال: Current Opinion in Oncology
سال: 2014
ISSN: 1040-8746
DOI: 10.1097/cco.0000000000000113